1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL, SODIUM SALT - Names and Identifiers
1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL, SODIUM SALT - Physico-chemical Properties
Molecular Formula | C40H76NaO10P
|
Molar Mass | 770.99 |
Storage Condition | −20°C |
1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOGLYCEROL, SODIUM SALT - Introduction
1-Palmitoyl-2-oleoylphosphatidylglycerol sodium salt (POPG-NA) is a phospholipid compound. It is linked by a 1-palmitoyl group and a 2-oleoyl group to the 3-position of glycerol, while a phosphate group is linked to the 1-position of glycerol, and a sodium ion is bound to the phosphate group.
The main properties of the POPG-NA are as follows:
-Physical Properties: The POPG-NA appears as a white solid with a large molecular weight.
-Solubility: POPG-NA has a certain solubility in water and can form micelles or lipid layer structure.
-Conformation: The POPG-NA molecule has two fatty acyl chains, which makes it have a certain degree of fluidity and softness.
POPG-NA has a variety of applications in biochemistry and biomedicine:
-Surfactant: POPG-NA can be used as a surfactant for the preparation of lipid nanoparticles and microemulsions.
-Carrier: POPG-NA can be used as a carrier for drug delivery systems, including gene delivery and protein delivery.
-Biological research: POPG-NA can be used to simulate the role of electronegative phospholipids in cell membranes and conduct related biological research.
The preparation method of POPG-NA generally includes the following steps:
1. Glycerides are obtained from natural sources or synthetic glycerol by chemical synthesis or extraction methods.
2.1-palmitoyl and 2-oleoyl are reacted with glycerol to form POPG.
3. react POPG with phosphoric acid to form POPG-NA.
Regarding safety information, POPG-NA are generally considered to be relatively safe when used under appropriate conditions. However, if it is necessary to use the compound, it is recommended to follow appropriate laboratory practices and refer to the relevant safety data sheets and operating instructions.
Last Update:2024-04-09 20:02:46